| 摘要 |
The invention relates to a new use of alpha-ketoglutarate for manufacturing of medical preparation for prophylaxis or treatment of undesired medical conditions related with the presence and/or activity of ureolytic bacteria in vertebrate, including a human being, mammal, bird, amphibian and fish, wheras the undesired medical conditions is a condition related with the presence and/or activity in the gastrointestinal tract, respiratory and/or urogenital system of ureolytic bacteria from the group including Helicobacter pylori, bacterial strains from the Brucella genus, urease-positive bacteria such as Ureaplasma ureolyticum and other alkalophilic bacteria, such as for instance B. pasteurii, urease-producing Yersinia enterocolica rods, ureolytic bacteria that participate in the formation of biofilm and mineralisation of deposits on catheters and other medical equipment, ureolytic bacteria causing infections of the mucous membrane in the oral cavity, gingival diseases, dental caries, causing formation of tartar, ureolytic bacteria responsible for formation of infectious stones in course of urinary system infections of the genii: Proteus, Ureaplasma, Klebsiella, Pseudomonas, Staphylococcus, Providencia, Corynebacterium, in particular P. mirabilis, and mycoplasmas causing genital tract - in particular its lower part infections, Mycoplasma hominis and U urealyticum. The invention also covers new medical preparations, dietary supplements, special medicated food and food/feed additives containing alpha-ketoglutarate, useful in prophylaxis and inhibition of colonisation of vertebrates, including humans, mammals, birds, amphibian and fish by harmful ureolytic bacteria, in particular organisms of human beings and domestic animals by Helicobacter pylori. |
