摘要 |
Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereof wherein A is OR , NHS(=O)R; wherein; Ris hydrogen, C-Calkyl, C-Calkylenecarbocyclyl, C-Calkylene-heterocyclyl; Ris C-Calkyl, C-Calkylenecarbocyclyl, C-Calkylenehetcrocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; --- deonotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C-Calkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C-Calkyl, C-Cа1kоху, hydroxyl, halo, haloC-Calkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C-Calkyl-carbonylamino, C-Calkylenecarbocyclyl and C-Calkyleneheterocyclyl; Ris hydrogen, C-Calkyl, C-CalkoxyC-Calkyl or C-Ccycloalkyl; R is hydrogen, C-Calkyl, C-Calkoxy, C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV. |