发明名称 |
CHINAZOLIN-4-ONE ALS INHIBITOREN DER HUMANEN PHOSPHATIDYLINOSITOL-3-KINASE DELTA |
摘要 |
Methods of inhibiting phosphotidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating disease, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo. |
申请公布号 |
DE60238779(D1) |
申请公布日期 |
2011.02.10 |
申请号 |
DE2002638779 |
申请日期 |
2002.08.27 |
申请人 |
ICOS CORP. |
发明人 |
SADHU, CHANCHAL;DICK, KENNETH O.;TREIBERG, JENNIFER;SOWELL, GREGORY C.;KESICKI, EDWARD A.;OLIVER, AMY |
分类号 |
A61K31/505;A61K31/517;A61K31/52;A61K31/53;A61P3/10;A61P7/08;A61P9/00;A61P9/10;A61P11/00;A61P17/04;A61P17/06;A61P19/02;A61P25/02;A61P27/02;A61P29/00;A61P31/04;A61P35/00;A61P35/02;A61P37/06;A61P37/08;A61P43/00;C07D403/12;C07D473/00;C07D473/16;C07D473/24;C07D473/30;C07D473/34;C07D473/38;C07D473/40;C07D487/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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