发明名称 |
COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS |
摘要 |
<p>Compositions and methods for antagonizing miRNAs that are overexpressed in chronic, non-healing wounds, as compared to healthy tissue, are disclosed. The miRNA antagonists are oligonucleotides that hybridize to selected pre-miENA or mature miRNAs and prevent the miRNAs from binding to and downregulating their target mRNAs. Methods of using the miRNA antagonists to treat inflammatory disorders, including to promote healing of chronic, non-healing wounds and acute wounds are provided.</p> |
申请公布号 |
WO2011017697(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
WO2010US44878 |
申请日期 |
2010.08.09 |
申请人 |
NEW YORK UNIVERSITY;TOMIC-CANIC, MARJANA;BREM, HAROLD |
发明人 |
TOMIC-CANIC, MARJANA;BREM, HAROLD |
分类号 |
C12N15/113;A61K31/7088;A61P17/02 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|