发明名称 |
PEPTIDES PROMOTING LIPID EFFLUX VIA ABCA1 AND ACTIVATING A LIPOPROTEIN LIPASE |
摘要 |
Disclosed herein are peptides and peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein. |
申请公布号 |
US2011033518(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
US20090937974 |
申请日期 |
2009.04.14 |
申请人 |
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发明人 |
REMALEY ALAN T.;AMAR MARCELO J.A. |
分类号 |
A61K9/00;A61K31/7088;A61K38/17;A61P3/00;A61P3/06;A61P9/00;A61P9/10;C07H21/00;C07K7/08;C07K14/775 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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