发明名称 |
REAGENTS FOR INDUCING AN IMMUNE RESPONSE |
摘要 |
The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell. |
申请公布号 |
US2011033522(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
US20080680052 |
申请日期 |
2008.09.26 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT & FELLOWS OF HARVARD COLLEGE;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
REINHERZ ELLIS L.;OH KYOUNG JOON;KIM MIKYUNG;WAGNER GERHARD;SUN ZHEN-YU J.;IRVINE DARRELL J.;BERSHTEYN ANNA |
分类号 |
A61K39/21;A61K9/127;A61K9/14;A61P31/18;A61P37/04;B82Y5/00;C07K16/08;C12N5/07;G06G7/60 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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