发明名称 |
METHODS RELATING TO AROMATASE INHIBITOR PHARMACOGENETICS |
摘要 |
Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject
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申请公布号 |
US2011033856(A1) |
申请公布日期 |
2011.02.10 |
申请号 |
US20100852957 |
申请日期 |
2010.08.09 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
LAZARUS PHILIP;SUN DONGXIAO |
分类号 |
C12Q1/68;C12Q1/48;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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