发明名称 |
14-3-3 ETA ANTIBODIES AND USES THEREOF FOR THE DIAGNOSIS AND TREATMENT OF ARTHRITIS |
摘要 |
Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3. |
申请公布号 |
EP2222704(A4) |
申请公布日期 |
2011.02.09 |
申请号 |
EP20080855660 |
申请日期 |
2008.11.26 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
MAROTTA, ANTHONY |
分类号 |
C07K16/18;A61K39/395;A61P19/02;C07K16/00;G01N33/53;G01N33/543 |
主分类号 |
C07K16/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|