发明名称 |
RECOMBINANT HUMAN FACTOR VIII DERIVATIVE |
摘要 |
2071875 9109122 PCTABS00005 A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA segment coding for the 90 kDa chain of human factor VIII and a second DNA segment coding for the 80 kDa chain of human factor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of 4 to about 100 amino acid residues of the B domain of human factor VIII, at least 4 of said amino acid residues originating from the C terminal of said domain; recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bond.
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申请公布号 |
CA2071875(A1) |
申请公布日期 |
1991.06.16 |
申请号 |
CA19902071875 |
申请日期 |
1990.12.06 |
申请人 |
KABI PHARMACIA AKTIEBOLAG |
发明人 |
ALMSTEDT, ANNELIE B.;HELLSTROEM, EVA M.;LARSSON, KERSTIN;LIND, PETER;SANDBERG, HELENA I.;SPIRA, JACK;SYDOW-BAECKMAN, MONA |
分类号 |
A61K38/43;A61K38/00;A61P7/04;C07K14/00;C07K14/745;C07K14/755;C07K19/00;C12N5/10;C12N15/09;C12N15/12;C12N15/85;C12P21/02;C12R1/91;(IPC1-7):C12N15/62;C12N15/57;C12N9/64 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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地址 |
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