| 发明名称 |
4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS |
| 摘要 |
<p>This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.</p> |
| 申请公布号 |
EP2280935(A1) |
申请公布日期 |
2011.02.09 |
| 申请号 |
EP20090738023 |
申请日期 |
2009.04.20 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ANDJELKOVIC, MIRJANA;CECCARELLI, SIMONA, M.;CHOMIENNE, ODILE;MATTEI, PATRIZIO |
| 分类号 |
C07C233/51;A61K31/197;A61K31/381;A61P3/06;A61P3/08;A61P9/12;C07C235/12;C07C237/12;C07D213/55;C07D333/24 |
主分类号 |
C07C233/51 |
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