The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating tRNA-like molecules with specific amino acids.
申请公布号
CA2391433(C)
申请公布日期
2011.02.08
申请号
CA20002391433
申请日期
2000.11.22
申请人
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人
HIROAKI, SUGA;DIMITRIOS, KOUROUKLIS;HIROHIDE, SAITO;LEE, NICK;BONZAGNI, NEIL