The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
申请公布号
CA2610888(C)
申请公布日期
2011.02.08
申请号
CA20062610888
申请日期
2006.06.07
申请人
MERCK & CO., INC.
发明人
ARMSTRONG, DONNA J.;HU, ESSA H.;KELLY, MICHAEL J., III;LAYTON, MARK E.;LI, YIWEI;LIANG, JUN;RODZINAK, KEVIN J.;ROSSI, MICHAEL A.;SANDERSON, PHILIP E.;WANG, JIABING