发明名称 |
METHODS FOR SELECTIVELY STIMULATING PROLIFERATION OF T CELLS |
摘要 |
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
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申请公布号 |
CA2164226(C) |
申请公布日期 |
2011.02.08 |
申请号 |
CA19942164226 |
申请日期 |
1994.06.03 |
申请人 |
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发明人 |
JUNE, CARL H.;THOMPSON, CRAIG B.;NABEL, GARY J.;GRAY, GARY S.;RENNERT, PAUL D.;FREEMAN, GORDON J. |
分类号 |
C12N5/0783;C12N15/02;A61K35/14;A61K38/00;A61K39/395;A61K48/00;A61P31/00;A61P35/00;C07K7/06;C07K7/08;C07K14/705;C07K14/725;C07K16/28;C12N5/02;C12N5/10;C12N5/18;C12N11/00;C12P21/08;C12Q1/02 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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