发明名称 |
Detection and Treatment of Schizophrenia |
摘要 |
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.
|
申请公布号 |
US2011028470(A1) |
申请公布日期 |
2011.02.03 |
申请号 |
US20080674018 |
申请日期 |
2008.07.31 |
申请人 |
TOKAI UNIVERSITY EDUCATIONAL SYSTEM;RENASCIENCE CO., LTD.;MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
ITOKAWA MASANARI;MIYATA TOSHIO;ARAI MAKOTO |
分类号 |
A61K31/5355;A61K31/4152;A61K31/4155;A61K31/416;A61K31/427;A61K31/4355;A61K31/44;A61K31/4709;A61P25/18 |
主分类号 |
A61K31/5355 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|