发明名称 |
THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS |
摘要 |
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1 - X2 - X3 - X4 - X5 - X6 - X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis. |
申请公布号 |
WO2011014707(A2) |
申请公布日期 |
2011.02.03 |
申请号 |
WO2010US43792 |
申请日期 |
2010.07.29 |
申请人 |
KAI PHARMACEUTICALS, INC.;KARIM, FELIX;BARUCH, AMOS;MACLEAN, DEREK |
发明人 |
KARIM, FELIX;BARUCH, AMOS;MACLEAN, DEREK |
分类号 |
A61K38/08;A61P3/14;A61P5/00;A61P5/20;C07K7/06 |
主分类号 |
A61K38/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|