| 发明名称 |
DIHYDROPYRIMIDONE AMIDES AS P2X7 MODULATORS |
| 摘要 |
<p>Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5, Ra and Rb are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.</p> |
| 申请公布号 |
WO2011012592(A1) |
申请公布日期 |
2011.02.03 |
| 申请号 |
WO2010EP60830 |
申请日期 |
2010.07.27 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;BROTHERTON-PLEISS, CHRISTINE E.;CAROON, JOAN MARIE;LOPEZ-TAPIA, FRANCISCO JAVIER;WALKER, KEITH ADRIAN MURRAY |
发明人 |
BROTHERTON-PLEISS, CHRISTINE E.;CAROON, JOAN MARIE;LOPEZ-TAPIA, FRANCISCO JAVIER;WALKER, KEITH ADRIAN MURRAY |
| 分类号 |
C07D239/22;A61K31/513;A61P3/00;A61P11/00;C07D401/12;C07D403/12 |
主分类号 |
C07D239/22 |
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