发明名称 |
LIPOSOMAL FORMULATIONS COMPRISING AN AMPHIPATHIC WEAK BASE LIKE TEMPAMINE FOR TREATMENT OF NEURODEGENERATIVE CONDITIONS |
摘要 |
Provided is the use of an amphipathic weak base having defined characteristics for the preparation of a pharmaceutical formulation for the treatment or prevention of neurodegenerative conditions. The amphipathic weak base can be encapsulated in a liposome. Also provided are pharmaceutical formulations and methods of use thereof for the treatment or prevention of neurodegenerative conditions. A specific and amphipathic weak base is tempamine (TMN). Further, tempamine can be loaded in sterically stabilized liposomes (SSL-TMN).
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申请公布号 |
US2011027351(A1) |
申请公布日期 |
2011.02.03 |
申请号 |
US20100903266 |
申请日期 |
2010.10.13 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM;HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED |
发明人 |
BARENHOLZ YECHEZKEL;OVADIA HAIM;KIZELSZTEIN PABLO |
分类号 |
A61K9/127;A61K31/4465;A61P25/00 |
主分类号 |
A61K9/127 |
代理机构 |
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