发明名称 |
IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE TRANSCRIPTION FACTOR FUNCTION AND TO TREAT TRANSCRIPTION FACTOR ASSOCIATED DISEASES |
摘要 |
The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor. The present invention also relates to various compounds described herein (e.g., a compound of Formula XI), their pharmaceutically acceptable salts and to methods of using said compounds as described herein. |
申请公布号 |
WO2011014299(A2) |
申请公布日期 |
2011.02.03 |
申请号 |
WO2010US37664 |
申请日期 |
2010.06.07 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER;OETTGEN, PETER;RIGBY, ALAN, C.;LIBERMANN, TOWIA |
发明人 |
OETTGEN, PETER;RIGBY, ALAN, C.;LIBERMANN, TOWIA |
分类号 |
C12Q1/68;A61K31/36;A61K31/52;G01N33/15;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|