发明名称 |
Simultaneous Method for the Preparation of a Mixture of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3-acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine |
摘要 |
The present invention relates to preparation and biological evaluation of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2′-chloro-5-androsteno[17,16-b]pyridine (5) as gastric proton pump inhibitor and their comparison to that of omeprazole, a clinically employed anti-gastric ulcer drug. Compound (4) exhibited dose dependent inhibition of histamine-stimulated acid secretion in gastric parietal cell with an IC50 value comparable to cimetidine. No mortality or behavioral abnormality of Swiss albino mice was observed under single-dose level of 1 g/Kg body weight of compound (4). Compound (4) further exhibited excellent anti ulcer activity in vivo against indomethacin induced ulcer.
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申请公布号 |
US2011028440(A1) |
申请公布日期 |
2011.02.03 |
申请号 |
US20090935877 |
申请日期 |
2009.03.26 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
BORUAH ROMESH CHANDRA;BORTHKUR MOYURIMA;BARTHAKUR MADAN GOPAL;RAO PARUCHURI GANGADHAR;KAR SUDIP KUMAR;CHINNIAH ANNALAXMI;GOSWAMI SUCHANDRA;DAS PRATAP KUMAR |
分类号 |
A61K31/568;A61P1/04 |
主分类号 |
A61K31/568 |
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