BENZO [E] [1, 3 ] OXAZIN-4-ONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS

摘要

Compounds of formula (I): wherein: W is O, N-H, N-alky!, N-alkenyl, N-alkynyl, N-aryl, N-heteroaryl or S; each X is independently CH or N; R1 is formula (b) or R3 is H, alkyl, NH2, OH, =0 or halogen; each A and B are independently CH or N; D is NHR4; R4 is H, alkyl, -C(O)- alkyl. -C(O)-NH2, -C(O)-NH- alkyl, -SO2- alky!, -SO2-NH2 or -SO2-NH- alkyl; R2 is aryl substituted with at least one nitrogen-containing group or R2 is a nitrogen-containing heteroaryl, cycloalkyl substituted with a nitrogen-containing group, nitrogen-containing cycloalkyl, C1-C6 mono alkylamino, C1C6 bis alkylamino, C1C6 acylamino, C1-C6 aminoalkyl, mono (C1C6 alkyl) amino C1-C6 alkyl, bis (C1C6 alkyl) amino C1C6 alkyl, C1-C6-acylamino or C1 C6 alkynyl-NR11; R11 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halogen, O-alkyl, NH-alkyl, N-dialkyl, -C(O)-R7, -C(O)-NH2, -C(O)-NH-R7, -SO2-R7, -SO2-NH2, -SO2-NH- R7, NH-acyl, NH-sulfonyl, NR7-acyl, NR7-suIfonyl, N-C(O)-NH-R7, N-SO2-NH-R7, N-C(O)-NR7R7 or N-SO2-NR7R7; and R7 is alkyl, aryl or heteroaryl, are useful as PI3K inhibitors and are useful in therapy.