发明名称 |
THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS |
摘要 |
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1 - X2 - X3 - X4 - X5 - X6 - X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.
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申请公布号 |
CA2769525(A1) |
申请公布日期 |
2011.02.03 |
申请号 |
CA20102769525 |
申请日期 |
2010.07.29 |
申请人 |
KAI PHARMACEUTICALS, INC. |
发明人 |
KARIM, FELIX;BARUCH, AMOS;MACLEAN, DEREK;DAS, KANAD;YIN, QUN |
分类号 |
A61K38/08;A61P3/14;A61P5/00;A61P5/20;C07K7/06 |
主分类号 |
A61K38/08 |
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