DERIVATIVE OF GLP-1 ANALOGUE OR ITS PHARMACEUTICAL SALTS AND THEIR USE

摘要

This invention discloses a derivative of a GLP-1 analogue or its pharmaceutical salts, wherein said GLP-1 analogue contains the amino acid sequence of general formula (I). The derivative of the GLP-1 analogue provided by this invention has the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. The derivative of the GLP-1 analogue or its pharmaceutical salts, or pharmaceutical compositions containing the derivative of the GLP-1 analogue or its pharmaceutical salts provided by this invention could be used widely in treating non-insulin-dependent diabetes, insulin-dependent diabetes or obesity. X1-X2-Glu-Gly-Thr-Phe-Thr-Ser-Asp-X10-Ser-X12-X13-X14-Glu-X16-X17-Ala-X19-X20-X21-Phe-Ile-X24-Trp-Leu-X27-X28-X29-X30-X31-X32-X33-X34-X35-X36-X37-X38-X39-Lys (I)