| 摘要 |
The invention relates to 2-amino-2-phenyl-alkanol-derived esters of general formula (I), where: R1 forms, with R3 and the nitrogen and carbon atoms to which they are respectively attached, a 4- to 7-membered heterocyclic compound, optionally substituted, in position a of the nitrogen atom, by radicals Ra and Rb that, separately from each other, can be a hydrogen or a straight or branched alkyl (1 to 4 C); and R2 is H or a CO-O-CHR4-OCOR5 radical for which R4 is a hydrogen or a straight or branched alkyl (1 to 4 C); and R5 is an alkyl optionally substituted by benzyloxycarbonylamino, acylamino, or by the residue of an amino acid, or is a heterocyclic compound; or R2 is a straight or branched alkyl (1 to 4 C), or an alkyl (2 to 4 C) substituted by OH, alkoxy, alkylthio, NH2, alkylamino, or dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-membered heterocyclic compound, assuming that said substituted alkyl is straight or branched and comprises at least 2 C between >N-R2 and the substituent, wherein, unless otherwise mentioned, alkyl or acyl are straight or branched (1 to 7 C), in the R or S forms thereof or in the form of the mixtures thereof, as well as the pharmaceutically acceptable salts thereof, if present. |
