ANTI-AIDS SECRETORY RECOMBINANT BCG VACCINE

摘要

A vaccine containing Mycobacterium bovis BCG which secretes a fused protein obtained by inserting a foreign antigen peptide to the surface of a molecule of a secreted protein having a signal peptide as a carrier. The BCG secretes a fused protein obtained by inserting a foreign antigen peptide to the surface of a molecule of an alpha -antigen originating in an acid-fast bacterium. As the fused protein has extremely enhanced antigenicity and immunogenicity, it is recognized, when inoculated into animals, by B cells which efficiently recognize the alpha -antigen, and can effectively induce the production of an antibody against the alpha -antigen. When the BCG itself is inoculated into an animal, it continues to secrete the fused protein while continuing to grow in the animal body, thus providing a very useful vaccine.