发明名称 HUMAN CHEMOKINE BETA-13
摘要 Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemokine polypeptides and for detecting altered levels of the polypeptide in a host.
申请公布号 WO9639521(A1) 申请公布日期 1996.12.12
申请号 WO1995US07294 申请日期 1995.06.06
申请人 HUMAN GENOME SCIENCES, INC.;SMITHKLINE BEECHAM CORPORATION;LI, HAODONG;SEIBEL, GEORGE 发明人 LI, HAODONG;SEIBEL, GEORGE
分类号 A61K38/00;A61K38/19;A61K48/00;C07K14/52;C12N1/19;C12N1/21;C12N5/10;C12N15/19;C12N15/63;(IPC1-7):C12N15/19 主分类号 A61K38/00
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