| 摘要 |
The present invention provides a method for minimizing the bone loss effect of a compound of formula (I) wherein R is -CH2CON(CH3) -n-CH2CH2CH2CH3 or SO(CH2)3CF2CF3, or a pharmaceutically acceptable salt thereof, and wherein said formula (I) compound is administered to a mammal in need of treatment, comprising concurrently or sequentially administering to said mammal an effective amount of a compound of formula (II) wherein each R1 is independently -H, -OH,-O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or OSO2(C4-C6 alkyl); and R2 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. Also provided is a method for minimizing bone loss induced by the administration of formula (I) compound comprising concurrently or sequentially administering a bone anabolic agent. Pharmaceutical compositions are also provided.
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