PORTABLE PERFUSION/OXYGENATION MODULE HAVING RESPIRATORY GAS DRIVEN, MECHANICALLY LINKED DUAL PUMPS AND MECHANICALLY ACTUATED FLOW CONTROL VALVE FOR SLOW PULSATILE CYCLING OF OXYGENATED PERFUSATE DURING IN VITRO CONSERVATION OF VIABLE TRANSPLANT ORGANS

摘要

A portable perfusion/oxygenation module (10) includes respiratory gas driven dual positive displacement pumps (22, 24) coupled to a stacked membrane oxygenator unit (16) for perfusion fluid oxygenation, a valving manifold (26) to control perfusate flow direction coupled to an organ chamber (18) designed to enable easy installation of organ and maintenance of intra and extra organ fluid pressure. The perfusion/oxygenation apparatus requires no electrical power, is compact with the total weight being less than 50 pounds. With low weight and low flow rate of gas required to pump the perfusate, the oxygen supply is capable of sustaining pumping operation for 24 hours without gas cylinder change. No movable membranes, diaphragms or electrical power are required to deliver oxygenated perfusate.