发明名称 |
COMBINATIONS OF QUINOLINONE DERIVATIVES AND 5-FU OR CPT 11 |
摘要 |
Organic compounds having the formulas (I) and (II) are provided where the variables have the values described herein. Medicaments include an anti-cancer drug selected from 5-FU or CPT 11 and a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treatin along with an anti-cancer drug selected from 5-FU or CPT-11. The medicaments may be used in treating cancer. The use of a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treating cancer in conjunction with an anti-cancer drug selected from 5-FU or CPT-11 is also provided.
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申请公布号 |
CA2481055(C) |
申请公布日期 |
2011.02.01 |
申请号 |
CA20032481055 |
申请日期 |
2003.04.04 |
申请人 |
CHIRON CORPORATION |
发明人 |
RENHOWE, PAUL A.;PECCHI, SABINA;MACHAJEWSKI, TIMOTHY D.;SHAFER, CYNTHIA M.;TAYLOR, CLARKE;MCCREA, WILLIAM R.;MCBRIDE, CHRISTOPHER;JAZAN, ELISA;HEISE, CARLA |
分类号 |
A61K31/4709;C07D487/08;A61K31/19;A61K31/47;A61K31/4745;A61K31/496;A61K31/4995;A61K31/513;A61K31/5377;A61K31/541;A61P9/00;A61P35/00;A61P43/00;C07D401/04;C07D401/14;C07D405/04;C07D405/14;C07D409/04;C07D413/04;C07D413/14;C07D417/04;C07D453/02;C07D471/04;C07D519/00 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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