发明名称 |
Compositions that inhibit wound contraction and methods of using same |
摘要 |
The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a peptide or a polypeptide. The invention provides, for example, a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide having more than three consecutive basic amino acids. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide containing the sequence arginine-glycine-aspartic acid and a basic amino acid sequence or a pharmaceutical composition comprising a peptide containing therein a sequence of six consecutive amino acid residues of which at least about four of the six amino acid residues are basic amino acid residues. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising decorin.
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申请公布号 |
US5851994(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19950473025 |
申请日期 |
1995.06.06 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
SCHREIBER, RONDA;POLAREK, JAMES |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K38/00;A61K38/02;C07K5/00;C07K7/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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