Medical uses of 39-desmethoxyrapamycin and analogues thereof

摘要

Disclosed is the use of a 39-desmethoxyrapamycin analogue according to Formula (I), wherein R1 represents (H,H) or =O and R2 and R3 each independently represent H, OH or OCH3; or a pharmaceutically acceptable salt thereof, for treating a medical condition resulting from neural injury or disease, for treating a medical condition affecting the central nervous system, wherein the medical condition requires a medicament to cross the blood-brain barrier or the treatment of cancer or B-cell malignancies, wherein the cancer or Bcell malignancy is resistant to one or more existing anticancer agent(s).