Formulation of radioprotective alpha, beta unsaturated aryl sulfones

摘要

Disclosed is a pharmaceutical composition for use in reducing toxic effects of ionizing radiation in a subject comprising between about 20mg/ml to about 60mg/ml of at least one radioprotective alpha, beta unsaturated aryl sulfone and at least one component selected from the group consisting of a) at least one chemically modified cyclodextrin selected from the group consisting of 2-hydroxypropyl-betacyclodextrin, 2-hydroxypropyl-gamma-cyclodextrin, and hydroxyethyl-betacyclodextrin in an amount between about 20 percent and about 60 percent w/v, b) a water soluble polymer selected from the group consisting of povidone in an amount between about 0.5 percent and about 20 percent w/v and PEG in an amount between about 25 percent and about 90 percent and c) N,N-dimethylacetamide (DMA) in an amount between about 10 percent and about 50 percent w/v, wherein the composition has a pH within the range of about 7.5 to about 9.2.