SUBSTITUTED DERIVATIVES OF AZOLONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to synthesis of drugs used for treatment of patients infected with Helicobacter. Invention proposes compounds of the formula (I), their pharmaceutically acceptable salts with acids or their stereochemical isomers where X and Y each means independently CH or N; R1, R and R each means independently hydrogen atom or C1-C4-alkyl; R and R each independently hydrogen, halogen atom, C1-C4--alkyl, C1-C4--alkoxy-group, hydroxy-group, trifluoromethyl-group, trifluoromethoxy-group or difluoromethoxy-group; Z means C=O or CHOH and Ar means phenyl possibly substituted with up to three substituents taken from hydroxy-group, C1-C4--alkyl, C1-C4--alkoxy-group, halogen atom, trifluoromethyl-group, tri-(C1-C4--alkyl)-silylhydroxy- -group, or pyridinyl substituted with hydroxy-group and C1-C4--alkylhydroxy-group; (A) means radical of the formulas (a-1), (a-2), (a-3), (a-4), (a-5). Invention describes a method of their synthesis and a pharmaceutical preparation containing derivatives of azolone of the formula (I) as an active component and a method of its preparing. EFFECT: improved method of synthesis. 5 cl, 1 tbl, 25 ex