发明名称 |
Solid dosage form of olmesartan medoxomil and amlodipine with reduced amounts of impurities and reducing sugars |
摘要 |
Disclosed is a solid dosage form comprising olmesartan, medoxomil and amlodipine or a pharmacologically acceptable salt thereof, wherein said solid dosage form is substantially free of reducing sugars. In particular the composistions have small amounts of the impurities 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazol-5-carboxylic acid and 3-ethyl-5-methyl-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methylpyridine-3,5-dicarboxylate. Also disclosed is the method of treating hypertension in a warm-blooded non-human animal and the use of a solid dosage form in the manufacture of a medicament for the treatment or prophylaxis of hypertension. |
申请公布号 |
NZ575422(A) |
申请公布日期 |
2011.01.28 |
申请号 |
NZ20070575422 |
申请日期 |
2007.10.12 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
BAUER, WOLFGANG;LICHEY, JOHANN;TEUBNER, ANDREAS;WADENSTORFER, ELMAR |
分类号 |
A61K31/4178;A61K31/4422;A61K31/549;A61P9/12 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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