| 摘要 |
Disclosed is the use of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3 BETA, 17 BETA -diol and 4-androsten-3, 17-dione in the manufacture of a medicament for treating or reducing the likelihood of acquiring a vaginal disease or condition caused by the atrophy of either or both the layer lamina propria and the layer muscularis of the vagina in postmenopausal women, said disease or condition selected from the group consisting of vaginal atrophy, atrophic vaginitis, narrowing of the vaginal cavity, shortening of the vaginal wall, dyspareunia, or insufficeient compactness of collagen fibres and sexual dysfunction. The medicament may also contain a selective estrogen receptor modulator for uterine and mammary gland protection against cancer. The medicament can be formulated for separate, sequential or simultaneous administration of the sex steroid precursor and the estrogen receptor modulator. The medicament could work by increasing the compactness of the collagen fibres of the lamina propria or by increasing the muscularis thickness of the vaginal wall. |
