| 摘要 |
Disclosed is a 6-amino(aza)indane compound of the formula Iwherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar carries 1 radical Ra. Ra being selected from the group consisting of alkyl, alkenyl, fluorinated alkenyl, cycloalkyl, X is N or CH; E is CR6R7 or NR3; R1 is alkyl, cycloalkyl, cycloalkylmethyl, alkenyl, fluorinated alkyl, fluorinated cycloalkyl, fluorinated cycloalkylmethyl, fluorinated alkenyl, formyl or alkylcarbonyl; R1a is H or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2, 3 or 4; R2and R2a each independently are H, CH3, CH2F, CHF2 or CF3; R3 is H or alkyl; R4, R5 independently of each other are selected from H, alkyl, alkoxy and fluorinated alkyl; R6, R7 independently of each other are selected from H, alkyl and fluorinated alkyl and the physiologically tolerated acid addition salts of these compounds. Also disclosed is a composition compromising said compound and the use of said compound in the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand e.g. a disease of the central nervous system i.e. depression.
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