发明名称 Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine
摘要 Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, N and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
申请公布号 US2011021578(A1) 申请公布日期 2011.01.27
申请号 US20080808197 申请日期 2008.12.17
申请人 GLAXO GROUP LIMITED 发明人 BERTHELEME NICOLAS;CHAN WAI NGOR;SCOTT JAQUELINE SANDRA;WARD SIMON E.
分类号 A61K31/44;A61K31/18;A61P25/18;C07C311/13;C07D211/70;C07D211/72 主分类号 A61K31/44
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