发明名称 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS
摘要 The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein the variables A, L1, L2, R2, R11, and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
申请公布号 US2011021492(A1) 申请公布日期 2011.01.27
申请号 US20090921177 申请日期 2009.03.12
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 CORTE JAMES R.;HU ZILUN;QUAN MIMI L.
分类号 A61K31/501;A61K31/50;A61P7/02;A61P9/10;C07D237/12;C07D403/12;C07D403/14;C07D498/04 主分类号 A61K31/501
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