发明名称 |
ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE |
摘要 |
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
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申请公布号 |
US2011021571(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20100883860 |
申请日期 |
2010.09.16 |
申请人 |
XENOPORT, INC. |
发明人 |
GALLOP MARK A.;YAO FENMEI;LUDWIKOW MARIA J.;PHAN THU;PENG GE |
分类号 |
A61K31/27;A61K31/195;A61K31/341;A61K31/381;A61K31/4164;A61K31/426;A61K31/4439;A61K31/455;A61P1/04;A61P1/08;A61P25/14;A61P25/30;A61P25/32;C07C271/22;C07D207/40;C07D207/416;C07D213/79;C07D213/80;C07D307/30;C07D307/68;C07D333/38;C07D401/04 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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