| 摘要 |
PROBLEM TO BE SOLVED: To improve the stability of telavancin at ambient temperatures.SOLUTION: Disclosed are hydrochloride salts of telavancin having a chlorine ion content of from about 2.4 wt.% to 4.8 wt.%. The disclosed salts have improved stability at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts. In one embodiment, the present invention relates to a telavancin salt having a chlorine ion content of form about 2.4 wt.% to about 4.8 wt.%. In another embodiment, the present invention relates to a composition comprising a telavancin hydrochloride salt and a water-soluble solvent system, the pH of the composition being in the range of about 2.5 to about 5.0. |
