摘要 |
Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed. |
申请人 |
THE POPULATION COUNCIL, INC.;VARIANO, BRUCE;SPECK, JEFFREY;SALLENT, MARIA, TERESA;EVANS, SIMONE |
发明人 |
VARIANO, BRUCE;SPECK, JEFFREY;SALLENT, MARIA, TERESA;EVANS, SIMONE |