Multi-phase compositions for an initial and delayed release of a vaginal medicament

摘要

PCT No. PCT/GB94/01950 Sec. 371 Date Jun. 24, 1996 Sec. 102(e) Date Jun. 24, 1996 PCT Filed Sep. 8, 1994 PCT Pub. No. WO95/07071 PCT Pub. Date Mar. 16, 1995The present invention relates to multi-phase compositions for treating vaginal infections, for example, infections caused by Trichomonas vaginitis. The compositions, which are preferably formulated as a cream or pessary, comprise a continuous phase containing anti-vaginitis medicament for rapid, initial release and porous particles adapted for the delayed release of anti-vaginitis medicaments. Metronidazole is the preferred anti-trichomal medicament.