发明名称 |
USE OF STEM CELLS TO REDUCE LEUKOCYTE EXTRAVASATION |
摘要 |
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non- embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential. |
申请公布号 |
CA2768576(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
CA20102768576 |
申请日期 |
2010.07.21 |
申请人 |
ABT HOLDING COMPANY |
发明人 |
WODA, JULIANA MEGAN;VAN'T HOF, WOUTER |
分类号 |
C12N5/071;A61K35/12;C12Q1/04 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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