BIOSYNTHETIC GENE CLUSTER OF NOCATHIACINS AND USE THEREOF

摘要

Provided is a biosynthetic gene cluster of antibiotic-Nocathiacins. The gene cluster comprises 37 genes related to biosynthesis of Nocathiacins: 8 genes related to biosynthesis of macrocyclic framework, 4 genes related to biosynthesis of indolic acid side chain, 6 genes related to deoxidized glycosyl biosynthesis, 5 genes of cytochrome P450 oxidoreductase, 2 genes of methyl transferase, 2 resistance genes, 3 regulation genes, 3 genes with unknown function, and 4 genes related to transcription and translation. Also provided are proteins coded by said gene cluster, expression vector and host cell comprising said gene cluster, and method for the production of Nocathiacins by using said gene cluster.