| 摘要 |
PURPOSE: An adsorptive purification method for iodixanol is provided to obtain Iodixanol with desired purity while minimizing the loss of final products. CONSTITUTION: A method for purifying iodixanol from N-acetyl cyclized iodixanol, cyclized iodixanol, or primary o-alkyl trimer using non-polar organic adsorbents, where the average pore diameter is smaller than about 30 nm. The adsorbent includes non-polar acrylic ester, di-vinyl benzene resins, poly-styrene di-vinyl benzene resins, and carbon adsorbents. Upwards of 30% of the backpeak levels and 60% N-acetyl cyclic iodixanol levels are reduced for a 5% loss of iodixanol.
|
