METHOD OF PREVENTING CANCEROGENIC ACTION OF METHYLNITROSOUREA IN EXPERIMENTAL ANIMALS

摘要

FIELD: medicine. ^ SUBSTANCE: in order to prevent cancerogenic action of methylnitrosourea in experimental animals, methylnitrosourea is introduced to experimental animals subcutaneously in combination with anticancerogen. Introduction of anticancerogen starts from the first day of experiment with forage simultaneously with methylnitrosourea. Methylnitrosourea is introduced in dose 2.5 mg per a rat in 0.2 ml of injection water five times with one week interval during 1.5 months into tissue of the same mammalian gland at the base of left front paw. As anticancerogen, curcumin is given with forage in dose 200 mg/kg of forage 4 times per week during 8 months. ^ EFFECT: method ensures prevention of cancerogenic action of methylnitrosourea in experimental animals, which includes application of polyphenol compound of curcumin in phase of cancerogenesis promotion, when process of healthy cell transformation into tumour cell takes place. ^ 3 tbl, 3 dwg