| 摘要 |
PURPOSE: A synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol is provided to secure environment-friendliness using a solvent mixture of low costs and to prepare iodixanol with high yield and purity. CONSTITUTION: A synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol comprises a step for performing dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide in a temperature range of about 10 to about 20deg.C using a solvent mixture comprising about 70 to about 90 vol% 1-methoxy-2-propanol and about 10 to about 30 vol% water or methanol in a concentration of about 0.8 to about 2.0 ml solvent per g 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide in the presence of about 0.30 to about 0.40 mole equivalents of epichlorohydrin. |
