发明名称 |
Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof |
摘要 |
The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the bispecific immunocytokine DNL construct comprises an IgG antibody attached to a Fab antibody fragment and a cytokine, wherein the IgG and the Fab bind to different target antigens which may be expressed on the same target cell. The bispecific immunocytokine DNL construct exhibits improved pharmacokinetics, with a longer serum half-life and significantly greater efficacy compared to cytokine alone, antibody alone, unconjugated cytokine plus antibody or even other types of cytokine-antibody DNL constructs. In a most preferred embodiment the construct comprises an anti-CD20 IgG antibody conjugated to an anti-HLA-DR Fab and IFNα2b, although other combinations of antibodies, antibody fragments and cytokines may be used to form the subject DNL complexes.
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申请公布号 |
US2011020273(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20100869823 |
申请日期 |
2010.08.27 |
申请人 |
IBC PHARMACEUTICALS, INC. |
发明人 |
CHANG CHIEN-HSING;GOLDENBERG DAVID M. |
分类号 |
A61K38/20;A61K38/18;A61K38/19;A61K38/21;A61K38/23;A61K38/28;A61K38/31;A61K38/37;A61P1/04;A61P3/10;A61P17/06;A61P19/02;A61P25/00;A61P35/00;C07C31/18;C07H21/02;C07K2/00;C07K14/00;C07K14/475;C07K14/485;C07K14/505;C07K14/52;C07K14/525;C07K14/54;C07K14/545;C07K14/55;C07K14/56;C07K14/565;C07K14/57;C07K14/585;C07K14/61;C07K14/62;C07K14/655;C07K16/00;C12N9/96 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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