发明名称 |
MONOCLONAL ANTIBODY AGAINST INTERLEUKIN-13 RECEPTOR ALPHA 1 (IL-13RALPHA1) |
摘要 |
The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.
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申请公布号 |
US2011020363(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20100828589 |
申请日期 |
2010.07.01 |
申请人 |
ZENYTH OPERATIONS PTY LTD. |
发明人 |
DUNLOP FELICITY MEREDITH;BACA MANUEL;NASH ANDREW DONALD;FABRI LOUIS JERRY;HILTON DOUGLAS JAMES;NICOLA NICOS A. |
分类号 |
A61K39/395;A61P1/00;A61P11/00;A61P29/00;C07K16/24;C07K16/28;C07K16/46;C12N5/20 |
主分类号 |
A61K39/395 |
代理机构 |
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