发明名称 |
GENOMIC EDITING OF GENES INVOLVED IN AMYOTROPHYIC LATERAL SCLEROSIS DISEASE |
摘要 |
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated ALS. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
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申请公布号 |
US2011023144(A1) |
申请公布日期 |
2011.01.27 |
申请号 |
US20100842666 |
申请日期 |
2010.07.23 |
申请人 |
SIGMA-ALDRICH CO. |
发明人 |
WEINSTEIN EDWARD;SIMMONS PHIL;CUI XIAOXIA |
分类号 |
A61K49/00;A01K67/027;A61P43/00;C12N5/10 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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