| 摘要 |
A preparation method of antitumor compounds, i.e. a preparation method of the compounds shown by general formula (I) or their pharmaceutically acceptable salts is provided. Wherein, R1 is selected from H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl or optionally substituted heterocyclic group. The compounds shown by formula (I) prepared according to the invention can inhibit tyrosine kinase Bcr-Ab1 and other kinases of SRC family (Lck, Fyn, Src, Hck) after decomposition in a living organism. Thus, the compounds shown by formula (I) or their pharmaceutically acceptable salts prepared according to the preparation method provided in the invention can be used for treating cancers. Compared with the known antitumor compounds, the compounds of the invention show better curative effect and lower side effect. |
